Comparison of treatment effects of different dosage of tamsulosin for patients with type Ⅲ prostatitis
10.3760/cma.j.issn.1008-6706.2017.20.026
- VernacularTitle:不同剂量盐酸坦洛新缓释片用于Ⅲ型前列腺炎的疗效比较
- Author:
Zhaowei YANG
;
Rongsheng ZHOU
- Keywords:
Prostatitis;
Dose-response relationship,drug;
Tamsulosin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(20):3137-3140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the treatment effects of different dosage of tamsulosin for patients with type Ⅲ prostatitis.Methods 150 patients with type Ⅲ prostatitis were selected as study objects.They were divided into control group and research group according to the digital table,each group in 75cases.The research group was treated with tamsulosin 2 tablets (0.4mg),1 time a day.The control group was treated with tamsulosin 1 tablet (0.2mg) + starch tablet 1 tablet,1 time a day.After treatment for 12 weeks,the clinical effects,NIH-CPSI score,white blood cell count and pH value,and adverse reaction between the two groups were compared.Results The total effective rate of the research group was higher than that of the control group(93.33％ vs.81.33％),the difference was statistically significant (x2 =4.881,P ＜ 0.05).After treatment,the pain,voiding symptoms,quality of life and NIH-CPSI scores in the research group were (5.13 ± 4.02) points,(2.52 ± 1.07) points,(3.64 ± 3.25) points,(9.19 ± 0.63) points,respectively,which were lower than those in the control group [(8.25 ± 3.54) points,(3.28 ± 1.87) points,(5.57 ± 3.62) points,(16.47 ± 0.38) points],the differences were statistically significant (t =5.044,3.055,3.436,85.693,all P ＜0.05).The white blood cell and pH value of the research group were (12.65 ± 5.88) x 109/L,(6.29 ±0.20),respectively,which were lower than those in the control group [(16.58 ±6.24) x 109/L,(6.73 ± 0.16)],the differences were statistically significant (t =3.970,14.878,all P ＜ 0.05).The single occurrence rate and total occurrence rate between the two groups had no statistically significant differences (x2 =0.340,0.207,0.000,0.000,0.362,all P ＞ 0.05).Conclusion The effect of tamsulosin in dose of 0.4 mg is better than 0.2 mg,and had no significant impact on safety.
