Changes and clinical significance of serum bilirubin and homocysteine in patients with acute cerebral infarction
10.3760/cma.j.issn.1008-6706.2017.20.031
- VernacularTitle:急性脑梗死患者血清胆红素、同型半胱氨酸的变化及意义
- Author:
Yingwei YANG
- Keywords:
Brain infarction;
Bilirubin;
Homocysteine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(20):3156-3158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of serum bilirubin,homocysteine in the pathogenesis of acute cerebral infarction.Methods 150 patients with cerebral infarction were selected as the study group,and at the same time,110 healthy people were selected as the control group.We used automatic biochemical analyzer to determine the serum bilirubin level and enzyme-linked immunoassay was used to quantitatively determine the plasma homocysteine levels.At last,the data were statistically analyzed.Results (1) The concentrations of total bilirubin,indirect bilirubin and direct bilirubin of the study group were (9.74 ± 3.36) μmoL/L,(5.82 ± 1.65) μmol/L (3.80 ± 1.47) rnol/L,respectively,which were obviously lower than those of the control group [(14.35 ± 4.27) μmol/L,(8.22 ± 2.53) μmol/L,(6.07 ± 2.03) μmol/L,t =-2.528,-2.366,-2.256,all P ＜ 0.05].The concentration of homocysteine of the study group was (22.56 ± 7.35)pmol/L,which was obviously higher than (6.98 ± 3.35)μmol/L of the control group,the difference was statistically significant (t =16.973,P ＜ 0.05).The concentration of homocysteine was related to both total bilirubin(rs =-0.101,P =0.004) and indirect bilirubin (rs =-0.153,P =0.037).But there was no correlation between homocysteine and direct bilirubin (rs =-0.067,P =0.231).Conclusion Homocysteine may be a risk factor for cerebral infarction.Serum bilirubin may be protective factor for cerebral infarction involved in the occurrence and development of cerebral infarction.
