Research progress of tumor cells and tumor microenvironmentderived exosomal miRNAs in carcinogenesis, tumor diagnosis and treatment
- VernacularTitle:肿瘤及其微环境源性外泌体miRNAs在致癌机制、肿瘤诊断和治疗中的研究进展
- Author:
Xiufeng XIE
;
Zhizhou SHI
- Keywords:
tumor;
microenvironment;
exosome;
miRNAs;
tumorigenic mechanism
- From:
Basic & Clinical Medicine
2017;37(9):1326-1330
- CountryChina
- Language:Chinese
-
Abstract:
Exosomal miRNAs, derived from tumor cells or their microenvironment, could promote the proliferation, migration and invasion of tumor cells;and enhance tumor metastasis via regulating information exchange between tumor cells and immune cells or metastatic target organs;and induce tumor resistance to cisplatin and gemcitabine;meanwhile, detecting the exosomal miRNAs in the serum and saliva of cancer patients suggested the potential of application in cancer diagnosis and prognosis assessment.
