Absorption Characteristics of Isoimperatorin from Notopterygium in Different Parts of Rat's Intestines
10.3870/j.issn.1004-0781.2017.09.007
- VernacularTitle:羌活中异欧前胡素在大鼠各肠段的吸收特点
- Author:
Niumin WANG
;
Jinyao SUN
;
Youxia WEI
;
Fuping JIA
;
Yaqi WANG
;
Chengsen PANG
- Keywords:
Notopterygium;
Isoimperatorin;
Intestinal absorption;
Intestinal perfusion,single-pass
- From:
Herald of Medicine
2017;36(9):978-981
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the absorption features of isoimperatorin in intestine of rat.Methods Establish a single-pass intestinal perfusion model of rat,take phenolsulfonphthalein as a marker for the detection of isoimperatorin concentration from crude extracts of notopterygium,and observe the absorption features of isoimperatorin and its reference substance in intestine of rat.Results The content of isoimperatorin in crude extracts was (0.43±0.02)% (n=5).The absorption parameters of duodenum,jejunum,ileum,colon were (5.28±0.82),(4.47±0.56),(4.17±0.94),(4.32±0.68)×10-5 cm·s-1,respectively.There were no significant differences among them (P>0.05).Compared with the reference substance of isoimperatorin,crude extracts showed better absorption features.Conclusion Isoimperatorin from crude extracts have better characteristics of absorption.This study can provide theoretical basis for design of notopterygium oral formulation.
