Cardiac neuroceptor imaging on acute myocardial ischemia model using 11C-methyldopamine
10.3760/cma.j.issn.2095-2848.2017.05.003
- VernacularTitle:急性心肌缺血模型的11C-甲基多巴胺心脏受体显像
- Author:
Weina ZHOU
;
Yulin HE
;
Xiangcheng WANG
;
Guojian ZHANG
;
Xia BAI
;
Xiyan HAO
;
Xuemei WANG
- Keywords:
Myocardial ischemia;
Sympathetic nervous system;
Positron-emission tomography;
Tomography,X-ray computed;
Deoxyepinephrine;
Ammonia;
Swine
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(5):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate 11C-MDA,a cardiac sympathetic nerve presynaptic molecular probe,in acute myocardial ischemia (AMI) and to compare with 13N-Ammonia myocardial perfusion imaging.Methods Twelve Bama miniature pigs were used to establish AMI models.11C-MDA and 13N-Ammonia PET/CT were performed before and after model establishment.The defect fraction,ratio of defect to normal region,defect volume of 11C-MDA and 13N-Ammonia PET/CT were calculated.Paired-t test and twosample t test were used.Results Eight models were established successfully and 4 pigs died.The defect fractions on 11C-MDA and 13N-Ammonia myocardial imaging were significantly different (13.4±3.3 vs 7.4±1.0,18.8±4.4 vs 4.8±1.0,10.5±4.2 vs 4.4±0.9;t values:4.901,8.864,4.030,all P＜0.001) at the first,third and sixth month post-model establishment.The ratios of defect to normal region on 11C-MDA and 13N-Ammonia PET/CT myocardial images were significantly different (0.47±0.14 vs 0.59±0.10,0.43±0.13 vs 0.61±0.09;t values:-2.166,-3.415,both P＜0.05) at the first and third month post-model establishment.The defect volumes on 11C-MDA and 13N-Ammonia PET/CT were significantly different ((4.20±0.34) vs (2.55±0.11) cm3,(10.66±0.71) vs (2.46±0.12) cm3,(5.95±0.50) vs (2.44±0.11) cm3;t values:12.925,32.149,19.440,all P＜0.001) at the first,third and sixth month post-model establishment.Conclusions Myocardial ischemia-reperfusion and cardiac sympathetic restoration might occur at different times.The recovery of myocardial ischemia-reperfusion is earlier than that of the cardiac sympathetic nerve.
