Changes and clinical significance of serum Nesfatin-1 in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes mellitus
10.16066/j.1672-7002.2017.05.012
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者血清Nesfatin-1的变化及意义
- Author:
Guojun ZHENG
;
Xiaoyan WU
;
Zhengxian SHI
;
Yan WANG
;
Rui LI
- Keywords:
Sleep Apnea;
Obstructive;
Diabetes Mellitus;
Type 2;
NUCB2;
Nesfatin-1
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2017;24(5):258-261
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate thechanges and clinical significance of serum Nesfatin-1 in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and type 2 diabetes mellitus (T2DM).METHODS 25 OSAHS cases who visited the department of otolaryngology, pneumology department, endocrinology department, physical examination center and sleep monitoring room from December 2014 to April 2015 were assigned as OSAHS group, and 25 patients with OSAHS and T2DM as OSAHS combination T2DM group, and 25 other patients as control group. All patient were took polysomnography, and the height, waist, neck circumference and BMI with all subjects were recorded. The serum Nesfatin-1 and fast blood glucose levels of all patients were measured.RESULTS The gender, age, height, waist and neck circumference had no statistical difference among all groups. The height and BMI in OSAHS group and OSAHS combination T2DM group were statistically significant difference compared with the control group (P<0.05); the FBG in OSAHS combination T2DM group and OSAHS group were significantly higher than that of the control group, and the FBG in OSAHS combination T2DM group were significantly higher than that of the OSAHS group, with statistically significant(P<0.05); The AHI in OSAHS combination T2DM group were significantly higher than that of the OSAHS group, with statistically significant(P<0.05); the serum Nesfatin-1 in OSAHS combination T2DM group and OSAHS group were significantly higher than that of the control group, with statistically significant(P<0.05); FBG, AHI and Nesfatin-1 were positively correlated with each other.CONCLUSION The serum Nesfatin-1 in patients with OSAHS combination T2DM are in a high level.
