Research advances in immune tolerance in chronic hepatitis B virus infection
10.3969/j.issn.1001-5256.2017.05.034
- VernacularTitle:慢性HBV感染免疫耐受研究进展
- Author:
Fengping WU
;
Shuangsuo DANG
- Keywords:
hepatitis B virus;
hepadnaviridae infections;
immune tolerance;
review
- From:
Journal of Clinical Hepatology
2017;33(5):949-953
- CountryChina
- Language:Chinese
-
Abstract:
Immune tolerance refers to the specific non-response or negative response of T and B lymphocytes to antigens.According to the period of formation,immune tolerance can be classified into central tolerance and peripheral tolerance.Immune tolerance to hepatitis B virus (HBV) after HBV infection is considered a major cause of chronic HBV infection.This article briefly reviews the roles of HBeAg,functional defects of dendritic cells,low response of cytotoxic T lymphocytes,T helper cells and cytokines,variations of HBV genotype and genome,and host gene polymorphisms in the development of immune tolerance in chronic HBV infection,as well as related research advances.
