Relationship between rheumatoid arthritis and periodontal diseases
10.3760/cma.j.issn.1007-7480.2017.05.007
- VernacularTitle:类风湿关节炎与牙周炎的相关性研究
- Author:
Lin ZHAO
;
Xiaofei WANG
;
Xiaoli ZHANG
- Keywords:
Arthritis rheumatoid;
Periodontitis;
Biomedical research
- From:
Chinese Journal of Rheumatology
2017;21(5):322-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective By collecting rheumatoid arthritis (RA) periodontal parameters,analyzing the general information and clinical indicators to understand the relationship between RA and periodontitis.Methods From December 2014 to May 2016,132 cases of RA,50 cases of the periodontitis group were enrolled.Their periodontal parameters,general data and clinical indicators were analyzed and the measurement data were compared with t test.Counting data was compared by Chi square or Fisher's exact test for statistical analysis.Results The prevalence rate of periodontal disease in patients with rheumatoid arthritis was high (73％).When the RA complicated with periodontitis group and RA without periodontitis group were compared,the C-reactive protein (CRP) [(43±33) mg/L,(30±27) mg/L,t=2.213,P＜0.05],erythrocyte sedimentation rate (ESR) [(50±30) mm/1 h,(38±25) mm/1 h,t=2.263,P＜0.05],rheumatoid factor (RF) [(319±368) U/ml,(174±228) U/ml,t=2.783,P＜0.05],anti-cyclic citrullinated peptide (CCP) [(511 ±700) AU/ml,(262±429)AU/ml,t=2.535,P＜0.05],the positive rate of anti-CCP [80 (83％),17 (47％),x2=17.522,P＜0.001],health assessment questionnaire (HAQ) (2.5±0.8),(2.2±0.8),t=2.011,P＜0.05) of the RA complicated periodontitis group was statistically significantly different,but disease activity score (DAS)28 (5.5±0.7,5.3±0.7,t=1.970,P＞0.05) was not statistically significantly different.The anti-CCP positive group and anti-CCP negative group were compared in the number of patients with missing teeth [22 (23％),15 (43％),x2=5.19,P＜0.05],missing teeth number (3.5±1.5,2.5±1.4,t=2.004,P＞0.05),probingdepth (PD) (5.3±1.4) mm,(5.0±1.4) mm,t=1.094,P＞0.05),clinicalattachmentLevel (CAL) (5.2±1.4) mm,(4.9±1.5) mm,t=0.946,P＞0.05),bleedingon-probing (BOP) [17 (18％),7 (20％),x2=0.106,P＞0.05) was not statistically significant.Periodontitis with RA group and periodontitis group were compared with the number of patients with missing teeth [21(42％),5(10％),x2=4.11,P＜0.05],number of missing teeth (1.10±0.29,1.20±0.40,t=0.638,P＞0.05),PD [(4.3±1.7) mm,(3.2±1.4) mm,t=4.902,P＜0.05],CAL [(3.9±2.0) mm,(3.4±1.7) mm,t=2.18,P＜0.05],BOP [18(36％),9(18％),x2=13.306,P＜0.05] and CRP [(30±26) mg/L,(20±16) mg/L,t=3.820,P＜0.05],ESR [(45±21) mm/1 h,(32±18) mm/1 h,t=3.047,P＜0.05],was statistically significantly different.Conclusion The incidence of periodontitis in patients with RA is high;periodontitis may have a certain promoting effect on RA,and RA may also have some promoting effects on periodontitis.
