Effect of Chronic Unpredictable Mild Stress and Sertraline on Vitamin D Metabolism in Rat Prefrontal Cortex
10.3870/j.issn.1004-0781.2017.06.004
- VernacularTitle:慢性应激和舍曲林对大鼠前额叶皮质维生素D代谢的影响
- Author:
Xiaoxue GONG
;
Ruili DANG
;
Yujin GUO
;
Hualin CAI
;
Pei JIANG
- Keywords:
Sertraline;
Vitamin D;
Stress,unpredictable mild,chronic;
Depression
- From:
Herald of Medicine
2017;36(6):606-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between vitamin D and depression and the effects of chronic unpredictable mild stress (CUMS) plus sertraline on vitamin D metabolism in rat brain.Methods Male SD rats were randomly divided into normal control group,normal control + sertraline group,CUMS group and CUMS+sertraline group.CUMS was used to build the animal model of depression.After chronic exposure to CUMS or sertraline (8 mg·kg-1·d-1) for 6 weeks,behavioral response (sucrose preference test) and vitamin D metabolism in the prefrontal cortex were analyzed.Results Compared with normal control group,6 weeks of CUMS procedure induced the rats to a depression-like state,decreased weight and sucrose preference,and increased the expression of enzymes involved in vitamin D activation and catabolism (CYP27B1 and CYP24A1,respectively) and vitamin D receptor (VDR) in rat prefrontal cortex.As compared with CUMS group,CYP27B1,CYP24A1 and VDR were significantly decreased in CUMS+sertraline group (P<0.01 or P<0.05).Conclusion CUMS activates vitamin D signaling in the brain of the animal models of depression,while sertraline alleviates depressive behavior and relieves stress-induced activation of vitamin D signaling,indicating that vitamin D signaling may be involved in the stress-induced depression.
