Research progress of interferons in cancer treatment and its mechanism
10.3969/j.issn.1001-1978.2017.09.003
- VernacularTitle:干扰素抗肿瘤机制及其治疗肿瘤的研究进展
- Author:
Tingting ZHANG
;
Jinqiu ZHONG
;
Yuzhu CAO
;
Jiawei WU
;
Wenxing CHEN
;
Aiyun WANG
;
Yin LU
- Keywords:
interferons;
tumor;
molecular mechanisms;
metastasis;
immunity;
clinical treatment
- From:
Chinese Pharmacological Bulletin
2017;33(9):1195-1199
- CountryChina
- Language:Chinese
-
Abstract:
The interferons(IFNs) are a family of the multifunctional cytokines, which are a kind of highly active and multifunctional glycoproteins.Studies in recent years have shown that IFNs exert a powerful antitumor effect by regulating the proliferation of tumor cells, suppressing tumor metastasis and angiogenesis, and activating antitumor immune response.Combined with other tumor treatment methods, it can inhibit the development of a variety of blood system tumors and solid tumors.In addition, the use of IFNs inducers or IFNs combined with emerging immunotherapy can significantly increase the effectiveness of tumor therapy.This review focuses on our understanding of antitumor mechanism and clinical application of IFNs, and provides some guidance for future research and clinical treatment.
