Efficacy and Safety of Alprostadil Injection in Treatment of Viral Hepatitis:A Meta-analysis
10.3870/j.issn.1004-0781.2017.06.022
- VernacularTitle:前列地尔注射液治疗病毒性肝炎疗效和安全性Meta分析
- Author:
Xiaolei REN
;
Yiqiu ZHAN
;
Zhen HE
;
Haiying ZHANG
;
Chunyan ZHANG
;
Wanyu FENG
- Keywords:
Alprostadil injection;
Hepatitis;
viral;
Meta-analysis
- From:
Herald of Medicine
2017;36(6):687-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of alprostadil injection in patients with viral hepatitis.Methods Medline,Embase,The Cochrane Library,CBMdisc,CNKI,Wanfang Database and VIP were searched.The quality of included studies such as randomization,blinding,allocation concealment and loss of follow-up were evaluated and meta-analysis was performed by RevMan5.1 software.Results In total,14 RCTs and 1 232 patients were included.Meta-analysis showed that in patients with viral hepatitis,the total effective rate of alprostadil injection treatment was significantly superior to that of conventional therapy (P<0.000 01).Serious adverse drug reactions (ADRs) induced by alprostadil injection were not reported.Conclusion Alprostadil injection is effective and safe for treating viral hepatitis.However,the evidence is not strong due to the generally low methodological quality of RCTs.Further high quality and large sample-sized randomized controlled trials and more pharmacoeconomics studies should be carried out.
