The latent infection of HSV-1 and stress-induced reactivation
10.3969/j.issn.1001-1978.2017.09.001
- VernacularTitle:Ⅰ型单纯疱疹病毒潜伏感染及其应激复发
- Author:
Zhuo LUO
;
Chang YAN
;
Yifang LI
;
Kurihara HIROSHI
;
Rongrong HE
- Keywords:
HSV-1;
latency;
reactivation;
stress;
type I interferon;
immune evasion
- From:
Chinese Pharmacological Bulletin
2017;33(9):1185-1190
- CountryChina
- Language:Chinese
-
Abstract:
Herpes simplex virus type Ⅰ(HSV-1) is a common pathogen, and human is the only natural host of it.Following a period of lytic replication in epithelial cells, HSV-1 enters axon terminals of sensory neurons and then travels via retrograde transport to the sensory ganglia where latency can be established.Upon the stimulation of some stressors, the latent virus can reactivate, leading to recurrent diseases.Therefore, to clarify the mechanism of HSV-1 latent infection and stress-induced reactivation will offer new insights into the prevention, treatment and control of HSV-1 infection.In this review, we describes the mechanisms underlying HSV-1 latent infection and stress-induced reactivation.
