Effects of sphingosine-1-phosphate andits receptors on angiogenesis in autoimmune diseases
10.3969/j.issn.1001-1978.2017.09.002
- VernacularTitle:1-磷酸鞘氨醇及受体对自身免疫性疾病血管新生的影响
- Author:
Zhengrong ZHANG
;
Hong WU
;
Li DAI
;
Wenyu WANG
;
Ran DENG
;
Feng LI
;
Jun FU
- Keywords:
sphingosine-1-phosphate;
sphingosine-1-phosphate receptors;
G protein coupled receptors;
autoimmune diseases;
angiogenesis;
inflammation
- From:
Chinese Pharmacological Bulletin
2017;33(9):1190-1194
- CountryChina
- Language:Chinese
-
Abstract:
Sphingosine-1-phosphate(S1P) is an important bioactive lipid produced from cell membrane sphingomyelin metabolism process.S1P and cell membrane surface S1P receptors(S1PR1-5) are G protein coupled receptors(GPCRs), which influence the formation of new blood vessels in the immune system via combining the related inflammatory signaling pathway.This review describes briefly the effects of S1P and S1PRs on autoimmune disease angiogenesis through intracellular signal transduction, such as rheumatoid arthritis, multiple sclerosis, colitis, systemic lupus erythematosus.Further research will be a new therapeutic target on vascular inflammation of autoimmune diseases.
