Research progress of endoplasmic reticulum stress in diabetic cardiomyopathy
10.3969/j.issn.1001-1978.2017.09.004
- VernacularTitle:内质网应激在糖尿病心肌病中的研究进展
- Author:
Yu ZHOU
;
Jing LI
;
Cuiyu BAO
- Keywords:
diabetes;
cardiomyopathy;
myocardial metabolic disorders;
microvascular disease;
endoplasmic reticulum stress;
research progress
- From:
Chinese Pharmacological Bulletin
2017;33(9):1200-1203
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy(DCM) is a disease independently related with coronary artery atherosclerotic heart disease, hypertensive heart disease, valvular heart disease, congenital heart disease and other heart diseases that are uniquely associated with diabetes mellitus, and the pathological manifestations of DCM are mainly myocardial hypertrophy, interstitial fibrosis, necrosis and apoptosis.Endoplasmic reticulum is the central location of many important cellular functions, and endoplasmic reticulum swelling and functional disorder in diabetic cardiomyocytes, high blood sugar can cause endoplasmic reticulum stress, suggesting that endoplasmic reticulum stress(ERS) may be involved in the pathogenesis of diabetic cardiomyopathy and development.Based on this, this paper summarizes the progress of ERS in diabetic cardiomyopathy from the pathogenesis of diabetic cardiomyopathy, unfolding protein reaction and the related role of ERS in DCM.
