Advances in p73-targeting anti-tumor drugs
10.3969/j.issn.1001-1978.2017.09.006
- VernacularTitle:以p73为靶点的抗肿瘤药物研究进展
- Author:
Hanchuan MOU
;
Zhikuan YANG
;
Yafeng BAO
;
Jihong ZHANG
- Keywords:
tumor suppressor;
p73;
TAp73;
apoptosis;
inhibitory proteins;
complex
- From:
Chinese Pharmacological Bulletin
2017;33(9):1207-1210
- CountryChina
- Language:Chinese
-
Abstract:
The transcription factor p73 belongs to the p53 family of tumor suppressors,and can be transcribed into different isoforms with either pro-or anti-apoptotic(TAp73 and △Np73)functions.However,the tumor suppressor activity of TAp73 is inhibited through complex formation with inhibitory proteins(e.g.△Np73,mutant p53,MDM2 and iASPP).Therefore,it is a kind of tumor therapy strategy to reactivate TAp73 through targeting these inhibitors directly or release TAp73 from the complex by targeting their interaction.This review discusses the possible strategies of targeting p73 for its reactivation and the acting mechanism of related compounds.
