Association between C1GALT1,DEFA polymorphisms and its susceptibility to IgA nephropathy in Chinese Han and Hui population in Gansu Province
10.3969/j.issn.1000-484X.2017.05.023
- VernacularTitle:中国甘肃汉/回族人群C1GALT1、DEFA基因多态性与IgA肾病易感性的关系
- Author:
Jing SICHENG
;
Yan JING
;
Weicui DU
;
Jia LIU
;
Tingwen XUE
- Keywords:
IgA nephropathy;
Single nucleotide polymorphisms;
rs1008898;
rs2738081
- From:
Chinese Journal of Immunology
2017;33(5):746-749,754
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between the C1GALT1 rs1008898,the DEFA rs2738081 polymorphisms and susceptibility to IgA nephropathy in Chinese Han and Hui population in area of Gansu Province and explore molecular markers to predict IgA nephropathy Methods: In this study,there were 146 patients with IgAN and 180 normal controls in Han people and 83 patients with IgAN and 100 normal controls in Hui people.Two SNPs as rs1008898 and rs2738081 were analyzed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-gene sequencing technology.The genotype and allele frequency of rs1008898 and rs2738081 were compared between patients with IgAN and normal controls.Results: Rs1008898 GG genotypes and G allele were over represented in IgAN patients compared with controls.Distribution of rs1008898 polymorphism in patients with IgAN and normal controls showed no difference in Hui people.Neither Han nor Hui population,rs2738081 polymorphism had difference between IgAN patients and normal controls.Conclusion: The G allele of rs1008898 probably has correlation with the genetic susceptibility of IgAN in Gansu Han people.
