The long-term toxicity study of TAP-SSL5 fusion protein
10.3969/j.issn.1005-1678.2017.05.002
- VernacularTitle:抗炎抗凝双效融合蛋白TAP-SSL5对大鼠长期毒性研究
- Author:
Zhaofei FANG
;
Houyuan HU
- Keywords:
staphylococcal superantigen like protein-5;
tick anticoagulant peptide;
fusion protein;
long-term toxicity
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):7-9,13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the long-term toxicity of anti-inflammatory and anticoagulant tick anticoagulant peptide (TAP)-staphylococcal superantigen like protein-5 (SSL5) fusion protein in normal rats.MethodsSD rats were intraperitoneally injected with TAP-SSL5 (1mg/kg, every other day) for eight weeks and followed up for one week.The general behavior, weight, blood routine test, blood biochemistry and organ indexe were measured.ResultsOur results showed that there were no significantly difference between the TAP-SSL5 treated rats and the control on general behavior, weight, blood routine test, blood biochemistry, organ indexe and pathology.ConclusionThe fusion protein TAP-SSL5 with little long-term toxicity for rats is proved to be a safe drug.
