Elderly patients with acute myeloid leukemia comparative study on the clinical curative effect of Cimicifuga Biejia decoction, decitabine combined with Ara-c+ ACR+ G-CSF chemotherapy
10.3969/j.issn.1005-1678.2017.05.061
- VernacularTitle:老年急性髓系白血病患者采用升麻鳖甲汤、地西他滨联合阿糖胞苷+阿克拉霉素+粒细胞集落刺激因子的化疗方案的临床疗效比较研究
- Author:
Jin ZHOU
;
Lianyu GUO
;
Zhaosheng LIU
- Keywords:
acute myeloid leukemia;
elderly patients;
cimicifuga Biejia decoction;
decitabine
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):186-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of shenmabiejia and decitabine combined with CAG chemotherapy regimens in elderly patients with acute myeloid leukemia, so as to provide suggestions for the treatment of elderly patients with acute myeloid leukemia.Methods120 elderly patients with acute myeloid leukemia were randomly divided into Chinese medicine group (40 cases) and Western medicine group (40 cases) and control group (40 cases).The traditional Chinese medicine group were treated with shenmabiejia combined with CAG chemotherapy regimens;the western medicine group with decitabine combined with CAG chemotherapy regimens;the control group received CAG therapy only.Clinical data, effect, ECOG score and adverse reactions were collected.ResultsCompared with control group, CR (χ2=10.131,8.020, P=0.001,0.005) and ORR (χ2=14.245,8.791, P=0.000,0.003) of Chinese medicine group and Western medicine group were higher, NR were lower than those in the control group(χ2=14.245,8.791, P=0.000,0.397).Compared with the control group, ECOG physical scores of Chinese medicine group and Western medicine group were lower (t=5.125,3.427, P=0.000,0.000).The incidence of group, pulmonary infection, fever, thrombocytopenia, nausea and vomiting, diarrhea, liver injury of traditional Chinese medicine was lower than in the control group (t=10.286,5.556,15.126,4.800,7.207,21.344, P=0.001,0.018,0.000,0.028,0.007,0.000).The incidence of pulmonary infection, fever and nausea and vomiting the probability in Western medicine group is higher than that of control group (t=11.782,8.456,4.036, P=0.000,0.004,0.045).The probability of adverse reaction of traditional Chinese medicine is lower than that of western medicine group.ConclusionShenmabiejia combined with CAG chemotherapy is superior to docetaxel combined with CAG chemotherapy for elderly patients with AML.
