The correlation study of BIS and OAA/S score in monitoring sedation with dexmedetomidine combined with small-dose of sufentanil
10.3969/j.issn.1005-1678.2017.05.127
- VernacularTitle:右美托咪定复合小剂量舒芬太尼用于镇静时BIS值与OAA/S评分的相关性研究
- Author:
Qihan CHEN
;
Xiaoze ZHANG
- Keywords:
dexmedetomidine;
sufentanil;
bispectral index;
observer's Assessment of Alertness and Sedation score;
correlation coefficient
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):376-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the accuracy of bispectral index (BIS) in monitoring the sedation level with dexmedetomidine combined with small-dose of sufentanil.And, to analyze the BIS value of the best opportunity for invasive manipulation with this sedation method.MethodsEighty elective operation patients, ASA Ⅰ~Ⅱ, were randomLy selected for the study.Before the start of anesthesia, small-dose of sufentanil 0.1μg/kg and dexmedetomidine were injected in vein in sequence.The loading dose of dexmedetomidine was 1.0μg/kg for 15 min and the maintenance dose was 0.3μg/kg for 5 min.The time-pint before the start of injection was recorded as T0.And, T1, T2, T3, and T4 respectively presented the infusion time of dexmedetomidine for 5min, 10min, 15min and 20min.According to these four time-points, 80 patients were randomLy divided into four groups: group T1, group T2, group T3,and group T4.The relevant HR, MAP, SpO2, BIS value, and OAA/S score were separately recorded.Analyze the correlation of BIS and OAA/S score, and the cutoff value of BIS for OAA/S score=1 was obtained by analyzing receiver operating characteristic (ROC) curve.ResultsThe compound use of dexmedetomidine and sufentanil significantly decreased HR.With this sedation method, BIS value was positively correlated with OAA/S score (r=0.95), and the best cutoff value of BIS values for OAA/S score=1 was 44.5.ConclusionThere was a good correlation between BIS and OAA/S score in monitoring sedation with dexmedetomidine combined with small-dose of sufentanil.BIS=44.5 could be regarded as a good monitoring index of invasive manipulation with this sedation method.
