Expression and significance of platelet derived growth factor B and its receptors α in skin lesions of recurrent condyloma acuminatum

VernacularTitle:血小板源性生长因子B及受体αmRNA在复发性尖锐湿疣皮损中的表达与意义
Author: Jun WANG ; Xiyin CHEN ; Wenbei LIU ; Xiaoli CHANG ; Caifeng HE ; Bihua JI
Keywords: condyloma acuminatum; growth factor,platelet-derived; receptor; real-time-PCR
From: Chongqing Medicine 2017;46(13):1773-1774,1778
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of platelet-derived growth factor B(PDGF-B) and PDGFR-α mRNA in the skin lesion of recurrent condyloma acuminatum(CA) and to explore its relationship with recurrent condyloma acuminatum.Methods The expressions of PDGF-B and PDGFR-α mRNA in the lesions of recurrent CA and Nonrecurrent CA were investigated by Real-Time-PCR,and the normal foreskins weretaken as controls.Results The PDGF-B and PDGFR-α mRNA levels in the re current CA group and non-recurrent CA group were significantly higher than those in the normal control group,the differences were statistically significant(P＜0.05).The expressions of PDGF-B and PDGFR-α mRNA in the recurrent CA group were higher than those in the non-recurrent CA group(P＜0.01).Furthermore,the expressions of PDGF-B and PDGFR-α mRNA before treatment in the recurrent CA group were higher than those after treatment(P＜0.01).Conclusion PDGF-B and PDGFR-α mRNA might haue a certain relation with CA recurrence.