Expression of vascular endothelial growth factor and endothelial growth factor receptor related Lnc RNA HOTAIR in hepatocellular carcinoma and their clinical significance
10.3760/cma.j.issn.1008-6315.2017.05.004
- VernacularTitle:长链非编码RNA HOX转录反义RNA相关内皮生长因子与内皮生长因子受体在肝癌组织中的表达及临床意义
- Author:
Jianzhi GAO
;
Fang XIE
- Keywords:
Long non-cording RNA;
HOX transcript antisense RNA;
Hepatocellular carcinoma;
Endothelial growth factor;
Endothelial growth factor receptor;
Signaling pathways
- From:
Clinical Medicine of China
2017;33(5):397-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of the signaling pathway-related LncHOTAIR on the invasion and metastasis of hepatocellular carcinoma(HCC) and provide experimental basis for the treatment of liver cancer with target gene level.Methods Thirty specimens of liver cancer and tissue adjacent to carcinoma on liver and gallbladder surgery surgical resection were collected in the People′s Liberation Army General Hospital from September 2012 to June 2013.Expression of LncHOTAIR,vascular endothelial growth factor(VEGF) and endothelial growth factor receptor(VEGFR) in Hepatocellular Carcinoma and Paracancerous Tissues were detected by Real-time Quantitative Real-time PCR,the relationship between the pathological features and the pathological features of the patients with HCC was analyzed.Results The expression of LncRNA HOTAIR,VEGF and VEGFR were higher in HCC tissues than that in adjacent tissues,which was closely related to tumor size(P=0.512,0.003,0.008),TNM staging(P=0.094,0.001,0.014),portal vein thrombosis(P=0.065,0.046,0.031),invasion and metastasis (P=0.002,0.046,0.031) and 2-year recurrence((P=0.001,0.003,0.021).Conclusion Lnc HOTAIR-related VEGF signal pathways are closely related to the development of liver cancer,si-HOTAIR is expected to become a new focus in the clinical treatment of liver cancer in the future.
