Clinical comparative study of effects of pure collagenase and collagenase combined ozone on lumbar disc herniation
10.3969/j.issn.1002-1671.2017.05.025
- VernacularTitle:单纯胶原酶与胶原酶联合臭氧治疗腰椎间盘突出症的临床对照研究
- Author:
Jianwei CHEN
;
Xiaobing LI
;
Weidong GONG
;
Peng ZHANG
;
Zhiqun WU
- Keywords:
collagenase;
ozone;
lumbar disc herniation
- From:
Journal of Practical Radiology
2017;33(5):742-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects of pure collagenase injection and collagenase combined with herniation injection of ozone on the treatment of lumbar disc herniation(LDH).Methods According to the principle of randomized controlled double blind, 100 patients with LDH were divided into 2 groups:pure collagenase group and combined treatment group.Changes of NRS value and Macnab score were observed and recorded at multiple time points after operation.The difference of the effect of the two kinds of operation was analyzed.Results Among the 50 patients in the simple treatment group,3 patients were lost to follow-up.Among the 50 patients in the combined treatment group,2 patients were lost to follow-up,and open surgery in 2 patients because of poor efficacy after the injection of 3 months and 6 months respectively.By analyzing the change of NRS value and Macnab score of 2 groups patients,there was no significant difference in the short-term and long-term efficacy between the 2 groups(P>0.05);The symptoms of the 2 groups were improved after operation.The curative effect was positively correlated with the recovery time, and the difference was statistically significant (P<0.05).Conclusion The curative effect of pure collagenase injection and the combined with herniation injection of ozone are both significant, and there is no significant difference in the clinical efficacy between the 2 kinds of operations.
