Influential factors of airflow limitation in patients with chronic obstructive pulmonary disease:an analysis using quantitative CT
10.3969/j.issn.1002-1671.2017.05.029
- VernacularTitle:CT定量分析COPD患者气流受限的影响因素
- Author:
Kai ZHANG
;
Lingyu ZHANG
;
Chengqi ZHANG
;
Jiqing SONG
;
Yuejiao HOU
- Keywords:
chronic obstructive pulmonary disease;
airflow limitation;
airway wall thickness;
computed tomography;
lung function
- From:
Journal of Practical Radiology
2017;33(5):758-761,768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlations of emphysema and airway wall thickness to chronic obstructive pulmonary disease(COPD) of airflow limitation by quantitative CT.Methods 40 COPD patients and other 40 normal controls underwent pulmonary function tests and following MSCT exams with inspiration.The square root of wall area of an airway with an internal area of 8 mm2 (Ai8) and the percentage of low attenuation volume(LAV%) of the whole lung and each lobes at the threshold of-950 HU were measured by a software of Thoracic VCAR.The Ai8 between the observation group and the control one was compared using SPSS2.2.The contributions of LAV% and Ai8 to predictions of FEV1/FVC and FEV1% were also evaluated.Results There was a significantly statistical difference in the Ai8 between the observation group and the control one.There were correlations between airflow limitation markers and all of LAV% as well as Ai8 (P<0.05 for all standardized coefficients).Only the Ai8 of right inferior lobar made a significant contribution to airflow limitation in the whole lung bronchus, and the LAV% of each lobes made a stronger contribution to airflow limitation than the Ai8 of right inferior lobe.Conclusion There is a significantly statistical difference in the Ai8 between the observation group and the control one.The LAV% may make a greater contribution to airflow limitation than Ai8 in COPD group.The influential factors of airflow limitation in order were LAV%, Ai8 of right inferior lobe and Ai8 of the other lobes.
