Establishment of rabbit subarachnoid hemorrhage model and the imaging findings of a little amount of subarachnoid hemorrhage in acute phase
10.3969/j.issn.1002-1671.2017.05.034
- VernacularTitle:兔急性少量蛛网膜下腔出血的模型建立及影像学表现
- Author:
Liang HUANG
;
Peiling LI
;
Zhaohua ZHAI
;
Long ZHAO
;
Xiangjun FANG
- Keywords:
subarachnoid hemorrhage;
rabbit model;
computed tomography;
magnatic resonance imaging
- From:
Journal of Practical Radiology
2017;33(5):777-780,787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the sensitivity of a little amount of subarachnoid hemorrhage (SAH) between CT and different MR sequences through animal experiment,to find a more sensitive way to diagnosis SAH.Methods 18 healthy adult white New Zealand rabbits were randomly divided into two experimental groups(group A and group B) and one control group(group C).Rabbit SAH model was established by injecting blood into the cisterna magna one time.All rabbits underwent CT and MR scan at 2 hours,48 hours after operation.The findings on CT and different MR sequences were observed and recorded.Results ①In experimental groups(group A and group B),MR FLAIR sequences in the diagnosis of a little amount of SAH was more sensitive than that on MR T1WI,T2WI and CT in acute phase.And the diagnosis sensitivity between MR FLAIR and CT was statistically significant(P<0.05).②Abnormal signs of SAH could not be found in group C.Conclusion ①Rabbit SAH model was established successfully which will be the foundation for the follow-up study of medical imaging.②MR FLAIR sequence is more sensitive to diagnose a little amount of SAH in acute phase,and may be used in the routine diagnosis of SAH in acute phase.
