Predictive value of soluble growth STimulation expressed gene 2 on major adverse cardiovascular events after acute myocardial infarction
10.3969/j.issn.1004-8812.2017.04.002
- VernacularTitle:可溶性生长刺激表达基因2蛋白对急性心肌梗死后主要不良心血管事件的预测价值
- Author:
Hongli MA
;
Yu PENG
;
Chao LI
;
Jinglei NIU
;
Yingzhi JIANG
;
Chenliang PAN
;
Zheng ZHANG
- Keywords:
Soluble growth STimulation expressed gene 2;
Percutaneous coronary intervention;
Acute myocardial infarction;
Major adverse cardiovascular events
- From:
Chinese Journal of Interventional Cardiology
2017;25(4):186-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of soluble growth STimulation expressed gene 2(sST2) on major adverse cardiovascular events(MACE) of acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).Methods The study included 148 patients with first episode of AMI admitted from January 2015 to May 2016 in the heart center of the First Hospital of Lanzhou University.Serum sST2 level before PCI was tested and all patients were followed up clinically for 6 months after PCI.Results 1.MACEs were found in 23 patients during follow up.The sST2 leveles were significantly higher in patients with MACEs than the non-MACE group [(44.50 ±5.32) ng/ml vs.(23.59±1.15) ng/ml, P=0.001].Pearson correlation analysis showed that serum sST2 were positively correlated with MACE and type Ⅲ procollagen amine terminal peptide (PⅢNP) but was not correlated with NT-proBNP.2.Serum sST2 found to be correlated with the body mass index, blood pressure, triglycerides, aspartate aminotransferase, left ventricular end-systolic volume (LVESV) and left ventricular ejection fraction (LVEF).3.The area under the ROC curve of sST2 to predict the occurrence of MACE after PCI was 0.787 which was higher than that of NT-proBNP.The area under curve of sST2 combined with NT-proBNP was 0.820.4.The survival rate of patients with serum sST2 level ≤29 ng/ml was higher than patients with sST2>29 ng/ml in 6 months after PCI.Conclusions sST2 is affected by a variety of factors.sST2 combined with NT-proBNP can improve the predictive value of MACE after PCI, and higher the level of sST2, higher the mortality rate in 6 months after PCI.
