Associations of polymorphism of leptin receptor gene Gln223Arg with asthma and metabolic syndrome
10.3969/j.issn.1000-484X.2017.05.005
- VernacularTitle:瘦素受体基因Gln223Arg位点多态性与哮喘和代谢综合征之间关系的研究
- Author:
Junjie GAO
;
Miao QIN
;
Ruijin XU
;
Jing ZHANG
;
Yunjie GE
- Keywords:
Asthma;
Metabolic syndrome;
Leptin;
Leptin receptor;
Gene polymorphism
- From:
Chinese Journal of Immunology
2017;33(5):660-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of polymorphism of leptin receptor gene Gln223Arg with asthma and metabolic syndrome.Methods: Collected 120 asthma patients,92 metabolic syndrome patients,54 asthma combined metabolic syndrome patients and 81 normal controls.According to the severity,the asthma patients were divided into mild-medium group and severe group.The serum leptin level was measured by ELISA,the genotypes of leptin receptor were analyzed by the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and statistcs of each subject′s MBI,blood pressure,lung function and fasting blood glucose were collected.Results: ①There were significant differences in genotype and allele frequency in leptin receptor gene Gln223Arg between the metabolic syndrome group,asthma combined metabolic syndrome group and normal control group(P<0.05).②The allele frequency and genotype in leptin receptor gene Gln223Arg were significant different between the severe asthma group and normal control group(P<0.05).③The serum leptin level,BMI and systolic blood pressure of AA+AG genotype group were significiant higher than GG genotype group(P<0.05),while the value of FEV1% and FEV1/FVC of lung function were lower than GG genotype group(P<0.05).Conclusion: Leptin receptor gene Gln223Arg polymorphism is correlated with asthma and metabolic syndrome,and by causing leptin resistance,the A allele might be the genetic factor that contribute to individual susceptibility for asthma and metabolic syndrome.
