Study on role of Th22 cells and its functional cytokine IL-22 in lupus nephritis
10.3969/j.issn.1000-484X.2017.05.025
- VernacularTitle:Th22细胞及其功能分子IL-22在狼疮性肾炎中的作用研究
- Author:
Liping GU
;
Guili YANG
;
Youfa CHEN
;
Shuchao TAO
- Keywords:
Th22 cells;
IL-22;
Lupus nephritis
- From:
Chinese Journal of Immunology
2017;33(5):755-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expressions of Th22 cells and IL-22 in peripheral blood of patients with Lupus nephritis (LN) and explore its significance.Methods: Patients of systemic lupus erythematosus (SLE) with no renal involvement (n=38),lupus nephritis (n=32) and healthy controls (n=10) were studied.Flow cytometry was utilized to quantify the percentage of Th22 cells in peripheral blood.Enzyme-linked immunosorbent assay was used to detect the levels of serum IL-22.The Th22 cells and The serum level of IL-22 among three groups were compared,and the correlation between Th22,IL-22 and SLE disease activity index score (SLEDAI) was analyzed.Results: Th22 cells in SLE group and LN group were significantly higher than those in healthy control group (P<0.01).Serum IL-22 level was also significantly higher than that of healthy control group (P<0.01);Th22 and IL-22 LN group were slightly higher than that in SLE group,but the difference was not significant (P>0.05).The proportion of Th22 cells and the level of IL-22 in LN group were positively correlated with the disease activity score SLEDAI.Conclusion: Th22 cells and IL-22 may play an important role in the pathogenesis of SLE and LN.