Research on the effect and adverse drug reaction of Boulardii yeast combined triple and quadruple therapy on eradicating helicobacter pylori
10.3969/j.issn.1005-1678.2017.05.011
- VernacularTitle:Boulardii酵母菌联合三联及四联疗法根治幽门螺杆菌的疗效及对不良反应改善情况的研究
- Author:
Haiding ZHANG
;
Jingmin YUAN
;
Weibo ZHUO
- Keywords:
Boulardiiyeast;
triple therapy;
quadruple therapy;
helicobacterpylori;
adverse drug reactions
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and adverse drug reaction of Boulardii yeast combined with triple and quadruple therapy on eradication helicobacter pylori (H.pylori).Methods240 cases of peptic ulcer patients of H.pylori positive were selected in our hospital from January 2014 to December 2015, according to different treatment were divided into the triple threapy group(n=60), the triple therapy union group (n=60), the quadruple therapy group (n=60) and the quadruple therapy union group (n=60).The triple threapy group were given clarithromycin and amoxicillin and pantoraazole;on the basis of this, the triple therapy union group were given Boulardiiyeast.the quadruple therapy group were given clarithromycin and amoxicillin and pantoraazole and CBS capsule, on the basis of this, the quadruple therapy union group were given Boulardiiyeast.The four groups were treated continuously for 14 days.14C-UBT, H.pylori eradication rate and adverse drug reaction in the four groups were evaluated five weeks after treatment.ResultsCompared with the triple threapy group and the quadruple therapy group, H.pylori eradication rate in the triple therapy union group(91.2%) and the quadruple therapy union group(94.7%) were improved obviously, and the adverse drug reactions (31.6%、29.8%) decreased significantly, the cumulative recurrence rate of H.pylori were significantly decreased, and the differences were statistically significant (P< 0.05).ConclusionBoulardii yeast combined with triple and quadruple therapy can obviously increase the H.pylori eradication rate, reduce the incidence of adverse drug reactions and the risk of recurrence.The reasonable treatment plan should be selected according to the actual situation.
