Effects of meglumine adenosine cyclophosphate on cardiac function and oxidative stress in patients with acute myocardial infarction
10.3969/j.issn.1005-1678.2017.05.032
- VernacularTitle:环磷腺苷葡胺对急性心肌梗死患者心功能及氧化应激水平的影响
- Author:
Hui ZHANG
;
Qian WANG
- Keywords:
acute myocardial infarction;
percutaneous coronary intervention;
meglumine adenosine cyclophosphate;
cardiac function;
oxidative stress
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):98-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of meglumine adenosine cyclophosphate administrated before percutaneous coronary intervention (PCI) on curative efficacy, cardiac function and oxidative stress in patients with acute myocardial infarction (AMI).Methods118 patients of AMI meeting the inclusion criteria were selected as research objects.According to therapeutic schemes, those patients were divided into the control group (n=52) and the observation group (n=66).Before PCI, the control group was given conventional treatments.Besides that, the observation group was given meglumine adenosine cyclophosphate.Then, the curative efficacy, indices of cardiac function and oxidative stress were compared.ResultsAfter the treatments, the observation group had higher rates of ST decrease (>50%), thrombolysis in myocardial infarction(TIMI)3 grade (90.9% vs76.9%,84.8% vs 69.2%, P<0.05) and lower peak concentration of creatine kinase isoenzyme(CK-MB), cardiac troponin(cTn)I[(140.6±26.5) U/L比(193.7±30.8) U/L,(1.92±0.24)μg/L 比(2.71±0.32) μg/L,P<0.05].After the treatment, indices of stroke volume (SV), cardiac output (CO) and left ventricular ejection function (LVEF) which reflect cardiac function in the observation group were statistically higher than those in the control group [(57.26±9.37)mL vs.(52.16±9.15)mL,(5.23±1.17) L/min vs(4.49±1.12)L/min,(0.62±0.12) % vs.(0.51±0.15)%,P<0.05].24 hours after PCI, as to oxidative stress, the observation group had a statistically lower level of malondialdehyde(MDA) and higher level of superoxide dismutase[(4.39±0.43)nmol/L vs.(6.45±0.46) nmol/L, [(87.12±10.34)U/mL vs.(68.29±9.48)U/mL), P<0.05].ConclusionMeglumine adenosine cyclophosphate administrated before PCI is effective for patients with AMI.And it can significantly improve cardiac function and alleviate oxidative stress.
