Influence of Clonidine on the Postoperative Analgesic Effect of Epidural Bupivacaine and Fentanyl.
10.4097/kjae.1996.30.4.487
- Author:
Kyeong Hee KIM
1
;
Jin Kyoung JANG
;
Jin Chul JOO
Author Information
1. Department of Anesthesiology, Kang Nam General Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Pain;
postoperative;
Anesthetics;
fentanyl;
Anesthetic techniques;
epidural;
local;
bupivacaine;
Pharmacology;
clonidine
- MeSH:
Anesthetics;
Anesthetics, Local;
Blood Pressure;
Bupivacaine*;
Catheters;
Clonidine*;
Fentanyl*;
Heart Rate;
Humans;
Incidence;
Injections, Epidural;
Pain Measurement;
Pharmacology
- From:Korean Journal of Anesthesiology
1996;30(4):487-492
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Epidural clonidine reduces pain after surgery. The aim of this study was to evaluate the effect of adding low-dose clonidine to continuous epidural local anesthetics and fentanyl on pam relief. METHODS: 100 patients scheduled for gynecologic low abdominal surgery were investigated. All patients were given 10cc of 0.25% bupivacaine with fentanyl 100 ug through epidural catheter. Group I was infused with combined 0.15% bupivacaine and fentanyl 5 ug/ml at a rate of 2cc/hr. Group II was infused with combined 0.15% bupivacaine and fentanyl 5 ug/ml and 150 ug of clonidine at a rate of 2cc/hr. Pain was assessed on a visual analogue pain scale for 2 postoperative days. Changes in blood pressure, heart rate, and incidence of side effects were observed. RESULTS: VAS observed 20min, 1hr, 1day, 2days after operation were significantly lower in Group II than Group I . Blood pressure and heart rates were significantly changed in Group II but not in Group I for 2 hours after epidural injection. The incidence of side effects was similar between Group I and Group II. CONCLUSIONS: Continuous low-dose epidural clonidine infusion reduces blood pressure and heatt rates significantly but enhances postoperative analgesic effect of combined epidural bupivacaine and fentanyl without increased side effects.
