Curative efficacy of tanreqing injection in treatment of Severe craniocerebral injury in patients with Pulmonary infection pathogen and its effects on Inflammatory factor
10.3969/j.issn.1005-1678.2017.05.047
- VernacularTitle:痰热清注射液对重型颅脑损伤患者肺部感染病原菌及炎症因子的影响
- Author:
Haoyuan SHEN
;
Libo LU
- Keywords:
tanreqing injection;
severe craniocerebral injury;
pulmonary infection pathogen;
inflammatory factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):142-144,148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study curative efficacy of tanreqing injection in treatment of severe craniocerebral injury in patients with pulmonary infection pathogen and its effects on Inflammatory factor.Methods80 patients of severe craniocerebral injury who received therapy from April 2012 to April 2015 in our hospital were selected as research objects.There were pulmonary wheezing, wheezing, shortness of breath, fever and other clinical symptoms.According to draw method,those patients were divided into the experimental group (n=40) and the control group (n=40).Two groups were given drug sensitivity test to give the corresponding antibacterial drugs, treatment for 2 weeks, The control group was treated with routine treatment, while the experimental group was on the basis of the control group, treated with tanreqing injection, every time 30ml, add 5% glucose Injection 250ml after mixing, intravenous infusion, 1 times a day.Then the curative effect, body temperature, pulmonary rales disappeared, cough disappeared time, the infection rate of pathogenic bacteria, neutrophils, white blood cell count, procalcitonin, high sensitivity C reactive protein recovery time, interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) level of two groups were compared.ResultsAfter treatment, the total effective rate of the experimental group was significantly higher than the control group[95.00%(38/40) vs 70.00%(28/40)] (P<0.05);Body temperature, pulmonary rales disappeared, cough and expectoration disappeared time was significantly shorter than the control group[(4.90±1.02)d vs (9.06±2.16)d,(6.02±1.21)d vs (10.85±2.37)d,(5.79±1.03)d vs (9.65±1.68)d](P<0.05);The positive rate of pathogenic bacteria was significantly lower than the control group[5.00%(2/40)vs 47.50%(19/40)](P<0.05);The recovery time of neutrophil, white blood cell count, procalcitonin and high sensitive C reactive protein was significantly shorter than the control group[(6.10±1.20)d vs (9.06±1.68)d,(4.72±0.97)d vs (7.34±1.23)d,(7.67±1.26)d vs (11.93±1.57)d,(7.21±1.02)d vs (11.29±1.73)d](P<0.05);IL-6、TNF-α level was significantly lower than the control group[(85.91±9.03)ng/L vs (102.08±10.42)ng/L,(17.38±1.01)ng/L vs (24.05±1.37)ng/L] (P<0.05).ConclusionTanreqing injection is well for severe craniocerebral injury,which can improve the clinical symptoms, protect the brain tissue, significantly reduce the pathogenic bacteria of pulmonary infection, and regulate the expression of inflammatory factors.
