Clinical research of tiotropium bromide combined with seretide in patients with chronic obstructive pulmonary disease at stable period
10.3969/j.issn.1005-1678.2017.05.075
- VernacularTitle:噻托溴铵联合舒利迭治疗慢性阻塞性肺疾病稳定期患者的临床疗效研究
- Author:
Xiaoyu WU
;
Liutao HE
;
Huachun CHEN
- Keywords:
TiotropiumBromide;
seretide;
chronic obstructive pulmonary disease;
stable period;
clinical efficacy
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):229-231
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the Clinical effect of Tiotropium Bromide combined with seretide in patients with chronic obstructive pulmonary disease at stable period.Methods84 patients with stable COPD from March 2015 to February 2016 in our hospital outpatient respiratory department were randomly divided into control group and treatment group.The control group was treated with Seretide, the treatment group was treated withtiotropium bromide on the basis of control group.Compared the lung function, blood gas analysis, 6-minute walking distance, dyspnea score and quality of life were between the two groups after six months of treatment.ResultsFVC, FEV1and FEV1/ FVC (%) in the treatment group were significantly higher than those in the control group (P<0.05).The score of quality of life and dyspnea in the treatment group were significantly lower than those in the control group (P<0.05).The 6MWD in treatment group was significantly longer than that in control group (P<0.05).PaCO2 was significantly lower in the treatment group than that in the control group, but PaO2 was significantly higher than that in the control group after six months treated(P<0.05).ConclusionThe combination of tiotropium bromide and seretide in patients with chronic obstructive pulmonary disease (COPD) is effective in improving pulmonary function, improving life therapy, and reducing the symptoms of dyspnea.
