Study on the efficacy and quality of life of tiotropium combined with sulpiride in elderly patients with moderate to severe COPD
10.3969/j.issn.1005-1678.2017.05.092
- VernacularTitle:噻托溴铵联合舒利迭对老年中重度COPD患者的疗效及生存质量研究
- Author:
Wensen YAN
;
Bin LI
;
Yan WANG
;
Xiaoyun JIANG
;
Jun WANG
- Keywords:
moderate to severe COPD;
elderly patients;
tiotropium;
seretide;
curative effect;
quality of life
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):277-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of tiotropium combined Seretide in the treatment of elderly patients with moderate to severe COPD clinical curative effect and the influence on the quality of life of patients.Methods114 cases of moderate or severe COPD in our hospital from January 2014 to January 2016,were randomly divided into observation group and control group, 57 cases in each group.The control group was treated with Seretide treatment, the observation group were treated by tiotropium combined with Seretide treatment, compared two groups of patients with curative effect and quality of life.ResultsBefore treatment, there were no significant differences in lung function index, MRC score, 6MWT and WHOQOL-100 scores between the two groups;After treatment, FEV1/FVC and FEV1% in the observation group were significantly higher than in the control group, and the difference was statistically significant (P<0.05);the dyspnea severity score (MRC) and six minute walk test (6MWT) in the observation group were significantly better than those in the control group, and the differences were statistically significant (P<0.05);the quality of life score (WHOQOL-100) in the observation group was significantly higher than in the control group, the difference was statistically significant (P<0.05).ConclusionTiotropium bromide combined with nimesulide in the treatment of elderly patients with moderate or severe COPD is effective, and can effectively improve the level of pulmonary function, improve the quality of life of patients.
