Changes before and after docetaxel chemotherapy and significances of T lymphocyte subsets of patients with non-small cell lung cancer
10.3969/j.issn.1005-1678.2017.05.105
- VernacularTitle:非小细胞肺癌患者多西他赛化疗前后T淋巴细胞亚群的变化及意义
- Author:
Haiying LIU
;
Guifu SUN
- Keywords:
non small cell lung cancer;
docetaxel;
T lymphocyte subsets
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):313-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes before and after docetaxel chemotherapy and significances of T lymphocyte subsets of patients with non-small cell lung cancer.MethodsThe clinical data of 100 cases of patients with non-small cell lung cancer treated in our hospital from January 2013 December 2016 were retrospectively analyzed, these patients were regarded as lung cancer group, another 100 cases of healthy subjects in our hospital received over the same period were selected as healthy group, the changes of T lymphocyte subsets of the two groups were statistically analyzed.ResultsThe CD+3, CD+3CD+4, CD+4/CD+8, NK cells before and after chemotherapy of the lung cancer group were significantly lower than the healthy group (P<0.05), the CD+3, CD+3CD+4, CD+4/CD+8, NK cells before chemotherapy were significantly lower than after chemotherapy (P<0.05), the difference of CD+4/CD+8 between the two groups was not significant;The CD+3, CD+3CD+4, CD+4/CD+8, NK cells of the disease control patients in the lung cancer group were significantly lower than the disease progression patients, healthy group (P<0.05), the differences of CD+3, CD+3CD+4, CD+4/CD+8, NK cells between the disease control patients and healthy group were not significant, the difference of CD+4/CD+8 between the two groups was not significant.ConclusionThe changes of T lymphocyte subsets before and after docetaxel chemotherapy of patients with non-small cell lung cancer can provide effective basis for clinical evaluation of cellular immune function and efficacy of chemotherapy of patients with non-small cell lung cancer, so is worthy of the clinical's full attention.
