Observation on effect of fentanyl combined with midazolam in painless bronchoscopy
10.3969/j.issn.1005-1678.2017.05.108
- VernacularTitle:芬太尼与咪唑安定联合在无痛支气管镜检查中的应用效果观察
- Author:
Zhonglong TAO
;
Yanwu WU
- Keywords:
painless;
bronchoscopy;
midazolam;
fentanyl
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):321-322,325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of fentanyl combined with midazolam in painless bronchoscopy.Methods76 patients underwent painless bronchoscopy in our hospital from October 2015 to October 2016 were randomly devided into the observation group and the control group, 38 cases in each group.The control group received conventional lidocaine local anesthesia, based on the control group, the observation group were given intravenous anesthesia using fentanyl and midazolam.Hemodynamic parameters (blood oxygen saturation (SpO2), heart rate (HR), diastolic blood pressure (DBP), systolic blood pressure (SBP)) were compared in the two groups before anesthesia (t1), 3 minutes after anesthesia (t2), 5 min after anesthesia (t3), wake up (t4), besides, incidence of adverse reactions were compared as well.ResultsAt t2, t3 time point, SpO2 was higher in the observation group than that in the control group, HR, DBP and SBP were lower than the control group, the difference was statistically significant (P<0.05);the incidence of side effects in the observation group was 5.26% (2/38), which was lower than that in the control group (26.31%, 10/38), the difference was statistically significant (P<0.05).ConclusionFentanyl combined with midazolam in painless bronchoscopy can effectively maintain the patient's hemodynamic stability and reduce the incidence of adverse reactions.
