Study on the mechanism of Minocycline hydrochloride ointment adjuvant therapy for chronic periodontitis study on the mechanism of minocycline hydrochloride adjuvant therapy for chronic periodontitis
10.3969/j.issn.1005-1678.2017.05.119
- VernacularTitle:盐酸米诺环素软膏辅助治疗慢性牙周炎的作用机制研究
- Author:
Xiaoyan HUANG
;
Danyan LU
- Keywords:
Minocycline hydrochloride ointment;
chronic periodontitis;
IL-8;
TNF-α
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):353-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and mechanism of minocycline hydrochloride ointment adjuvant therapy for chronic periodontitis.Methods86 patients of chronic periodontitis who received therapy from August 2013 to June 2015 in our hospital were selected.According to random number table, those patients were divided into the experimental group (n=43) and the control group (n=43).The control group was treated on the basis of the foundation treatment with tinidazole Oral Sticking Tablets and the experimental group were treated on the base of the foundation treatment with Minocycline hydrochloride sustained-release ointment, the levels of hs-CRP, TNF-a, IL-8 and IL-10 in gingival sulcus fluid were measured before and after treatment, the indexes of PLI, PD, SBI and AL were recorded,at the same time the clinical curative effect between two groups was compared.ResultsThe effective rate of the experimental group(95.35%) was higher than the control group(81.40%),the difference was statistically significant (P<0.05);Compared with before treatment, two groups general situations and inflammation factors changed after treatment,plaque index, periodontal pocket probing depth, gingival sulcus bleeding index and adhesion levels of the experimental group were lower than the control group after treatment, the PD, SBI, AL and PLI in the experimental group were significantly lower than that of the control group, and the hs-CRP, TNF-a and IL-8 levels were lower than the control group, IL-10 was higher than the control group after treatment(P<0.05).ConclusionMinocycline hydrochloride ointment is well for chronic periodontitis,which can effectively relieve periodontal chronic inflammation, improve clinical efficacy, the underlying mechanism may be related to the reduction of IL-8 and TNF-α levels in gingival crevicular fluid.
