Relationship between C-erbB-2, p-Akt protein expression and the efficacy of NAC in breast cancer
10.3969/j.issn.1005-1678.2017.05.124
- VernacularTitle:C-erbB-2、p-Akt蛋白表达与乳腺癌NAC疗效关系探讨
- Author:
Guotao FANG
;
Qi ZHANG
- Keywords:
human epidermal growth factor receptor-2;
phosphorylated protein kinase B;
breast cancer;
neoadjuvant chemotherapy
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):368-370,373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of human epidermal growth factor receptor-2 (C-erbB-2), phosphorylated protein kinase B (p-Akt) and the effect of neoadjuvant chemotherapy (NAC) in breast cancer.MethodsSelected May 2014 to December 2015 in quasi in our hospital for surgical treatment of 114 cases of patients with breast cancer research, the immunity group dyeing expression levels of C-erbB-2 and p-Akt detection NAC patients before treatment in breast cancer, its relationship with the clinicopathological features of patients, NAC recent curative effect analysis.Results114 patients c-erbB-2 positive 79 cases 69.30% p-Akt positive in 77 cases (67.54%) and breast cancer c-erbB-2 positive rate, p-Akt positive rate of main and tumor differentiation degree, the occurrence of lymph node metastasis (P<0.05);negative c-erbB-2 expression in patients with NAC total effectiveness 80.00% significantly higher than the 54.43% of positive patients (P<0.05);p-Akt negative expression patients with NAC total efficiency 75.68% significantly higher than positive patients of 55.84% (P<0.05).ConclusionThe high expression of p-Akt and C-erbB-2 protein in breast cancer tissue decreased the sensitivity of NAC treatment, and the effect was not good.
