Clinical significance of detection of GDF3,PSA combined with MUC1 for diagnosis of breast cancer
10.3969/j.issn.1005-1678.2017.05.131
- VernacularTitle:人生长分化因子3、前列腺特异性抗原与黏蛋白1联合检测在乳腺癌诊断中的临床意义
- Author:
Qiong WANG
;
Jianjun HU
;
Yanxia LI
- Keywords:
breast cancer;
growth differentiation factor 3;
prostate specific antigen;
mucin 1;
tumor markers
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(5):388-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of detection of growth differentiation factor 3(GDF3), prostate specific antigen(PSA) combined with mucin 1(MUC1)for diagnosis of breast cancer.Methods50 cases of breast cancer were selected as the breast cancer group, 50 cases of benign breast disease were selected as the benign breast disease group, and 50 healthy people were selected as the normal group.GDF3, PSA, MUC1 and tumor markets carbohydrate antigen(CA)15-3,CA125,carcinoembryonic antigen(CEA) were detected, and sensitivity, specificity and accuracy were analyzed.ResultsCompared with benign breast disease group and normal group, GDF3, PSA and MUC1 in breast cancer group were higher(P<0.05), CA15-3, CA125 and CEA were higher(P<0.05).The sensitivity, specificity and accuracy of PSA+MUC1 were higher than other group(P<0.05),the sensitivity, specificity and accuracy of combined detection of GDF3, PSA and MUC1 were higher(P<0.05).ConclusionDetection of GDF3 combined with MUC1 and PSA for early diagnosis of breast cancer has more diagnostic significance.