Aging and aging related neurodegenerative disease models and drug screening based on Caenorhabditis elegans:research progress
10.3867/j.issn.1000-3002.2017.05.008
- VernacularTitle:秀丽隐杆线虫衰老与衰老相关神经退行性疾病模型及药物筛选研究进展
- Author:
Xiaoli XUE
;
Jianqin ZHANG
;
Shaojuan SONG
;
Zhenyu LI
;
Xuemei QIN
- Keywords:
Caenorhabditis elegans;
aging;
neurodegenerative disease;
drug screening
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(5):429-438
- CountryChina
- Language:Chinese
-
Abstract:
Caenorhabditis elegans is a very important model organism in life sciences. C. elegans has been widely used in research on life sciences, especially in drug screening and the mechanism of drugs, thanks to some of their prominent characteristics, including a short life,short generation cycle, and easy culture and observation. Aging is a complex process, which is the result of multiple factors. There are mainly three types of anti-aging signal pathways in C. elegans, including insulin-insulin-like growth factor-1 signal pathway, diet-restricted signaling pathway and mitochondrial respiratory chain/ATP synthesis pathway. In this paper, we reviewed the aging models based on the above three signaling pathways and the progress in anti-aging drugs based on the above aging models. In addition, a number of C. elegans models of aging-related neurodegenerative diseases can be obtained by using transgenic or chemical mutagenesis. Thus, this paper reviewed the transgenic models of C. elegans associated with neurodegenerative diseases, including theα-synuclein transgenic model of Parkinson disease, theβ-amyloid deposition model of Alzheimer disease, and the polyQ of Huntington disease, and summa?rized the effective drugs based on the above disease models. This review will provide reference for the study of C. elegans in the future screening of anti-aging drugs and drug screening for the prevention and treatment of neurodegenerative diseases.
