Diagnostic value of serum homocysteine level in patients with colon cancer

VernacularTitle:血清同型半胱氨酸水平对结肠癌的诊断价值分析
Author: Xiuli GUO ; Shiwei YAO ; Peilin CUI ; Hui ZHAO ; Youqing XU
Keywords: Homocysteine; Colon cancer; Tumor marker; ROC curve
From: Clinical Medicine of China 2017;33(5):408-410
CountryChina
Language:Chinese
Abstract: Objective To investigate the diagnostic value of serum homocysteine in the diagnosis of colon cancer.Methods The performance rate method was used to detect the level of serum homocysteine(Hcy) in colon cancer group(50 cases) who were treated in Beijing Tiantan Hospital Affiliated to Capital Medical University from March 2011 to June 2016 and control group(50 cases).The expression of independent samples t test was used to analysis of the difference of the Hcy levels between the two groups.The ROC curve was used to evaluate the value of Hcy in diagnosis of colon cancer.Results The serum Hcy level in colon cancer group was (18.6±8.9) μmol/L,in healthy control group was (10.7±4.3) μmol/L,colon cancer group serum Hcy levels were significantly higher than those of healthy control group,there was significant difference(t=5.627,P<0.01).AUC of ROC curve was 0.775,cut-off value of 18.5 μmol/L,sensitivity was 0.50,specificity was 0.94,95%CI was 0.682-0.868(P<0.01).Conclusion Serum Hcy can be used as a reference index of the diagnosis of colon cancer.