Expression and clinical significance of HSPA2 in pancreatic cancer
10.19405/j.cnki.issn1000-1492.2017.08.017
- VernacularTitle:HSPA2在胰腺癌中的表达及其临床意义
- Author:
Yang WU
;
Qiang HUANG
- Keywords:
pancreatic cancer;
HSPA2;
invasion metastasis
- From:
Acta Universitatis Medicinalis Anhui
2017;52(8):1179-1182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of HSPA2 mRNA and protein in pancreatic cancer and corresponding adjacent nontumorous tissues, and investigate the expression of HSPA2 protein in pancreatic cancer and its association with clinicopathological characteristics.Methods Western blot and qPCR (real-time quantitative PCR) was used to evaluate HSPA2 expression in pancreatic cancer and corresponding adjacent nontumorous tissues.Immunohistochemistry was used to investigate the HSPA2 expression in pancreatic cancer and its association with clinicopathological characteristics.Results Both the mRNA and protein levels of HSPA2 were significant higher in pancreatic cancer tissues than those in their paired adjacent nontumorous tissues.High HSPA2 expression was detected in 68.8% (55/80) of pancreatic cancer tissues.HSPA2 protein expression was significantly associated with tumor differentiation, vascular invasion, and status of metastasis (P=0.011,0.005,0.012).Conclusion HSPA2 expression is elevated in pancreatic cancer, and positively correlated the process of invasion, metastasis and progression of pancreatic cancer.
