Role of ADAM8 in tumor metastasis

VernacularTitle:ADAM8在恶性肿瘤转移中的作用研究进展
Author: Qi JIA ; Zhaoguo LIU ; Suyun YU ; Lichuan CHEN ; Pingting ZHU ; Wenxing CHEN ; Aiyun WANG ; Yin LU
Keywords: tumor; tumor metastasis; a disintegrin and metalloproteinase 8; ECM; mechanisms; therapeutic strategy
From: Chinese Pharmacological Bulletin 2017;33(8):1037-1040
CountryChina
Language:Chinese
Abstract: Tumor metastasis is one of the important biological characteristics of malignant tumor,which is closely related with the prognosis of the cancer patients.High expression of ADAM8 in varieties of tumors was revealed in many recent studies,and such aberrant expression played a crucial role in regulating of tumor metastasis.Studies showed that overexpression of ADAM8 attenuated the intercellular adhesion effect,promoted tumor angiogenesis,and enhanced the degradation of ECM as well as the releasing of cytokines.Therefore,suppression of ADAM8 may lead to inhibition of tumor metastasis,which makes ADAM8 a particular attractive target as it can be used as a prognostic indicator and a potential therapeutic target of malignant tumor.A review about the relations between ADAM8 protein′s abnormal expression and tumor occurrence was discussed in this paper,also include discussion about the mechanisms of ADAM8 protein′s disorder-induced tumor formation,as well as therapeutic strategies based on ADAM8-targeted,which may provide references for follow-up research and clinical treatment.