Progress on chemokines participating in Alzheimer′s disease
10.3969/j.issn.1001-1978.2017.08.004
- VernacularTitle:趋化因子参与阿尔茨海默病的研究进展
- Author:
Piao LUO
;
Shifeng CHU
;
Tianbi ZHU
;
Naihong CHEN
- Keywords:
Alzheimer′s disease;
neuroinflammation;
chemokines;
neurofibrillary tangles;
amyloid plaques;
receptors
- From:
Chinese Pharmacological Bulletin
2017;33(8):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
Chemokines play pleiotropic roles in the pathology of Alzheimer′s disease(AD),a chronic inflammatory disease of central nervous system.The neuropathological features of AD include neurofibrillary tangles,amyloid plaques,neuroinflammation,and neuronal synaptic loss.Chemokines are involved in the pathogenesis of AD by activating or regulating inflammatory cells or glial cells,playing dual key roles of the pro-and anti-inflammatory properties in AD.The levels of chemokines in serum,cerebrospinal fluid and brain tissue of AD patients are changed accordingly.This review summarizes the role of chemokines and their receptors in AD in the biological activities and unveils the changing rules,aiming to provide new strategies for clinical treatment of AD.
