Research progress in metabolic activity of natural killer cells in patients with chronic hepatitis B virus infection
10.11855/j.issn.0577-7402.2017.07.16
- VernacularTitle:慢性乙型肝炎患者自然杀伤细胞代谢活性研究进展
- Author:
Li SUN
;
Huibin GAO
;
Ping ZHAO
- Keywords:
hepatitis B;
chronic;
natural killer cells;
mammalian target of rapamycin
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(7):656-660
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B is a world-wide health problem and now at least 250 million people have been infected with hepatitis B virus. Current treatment of hepatitis B rarely achieves a cure because the viral replication template which called covalently closed circular DNA (cccDNA) are resistant to conventional therapies. The phenotype and function of natural killer cells from chronic hepatitis B patients are different to those from acute hepatitis B patients, suggesting that the function of NK cells may be related to clearance of HBV. Some studies have suggested that the differentiation, development and activation of natural killer cells are controlled by the mammalian target of rapamycin. The present review will mainly focus on the biology of hepatitis B virus, the differentiation and development of natural killer cells, and the progress of metabolism of natural killer cells.
