Clinical analysis of drug hypersensitivity syndrome in 22 children

VernacularTitle:儿童药物超敏反应综合征22例临床分析
Author: Cong LIU ; Hongmei XU ; Liping TAN ; Lin YANG
Keywords: drug hypersensitivity syndrome; fever; hepatic function lesion; glucocorticoid
From: Journal of Clinical Pediatrics 2017;35(7):522-524
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical diagnosis and treatment of drug hypersensitivity syndrome (DIHS) in children. Method The allergenic drugs, clinical manifestations, laboratory examinations, treatment effects, complications and prognosis in 22 children with DIHS were analyzed retrospectively. Results All 22 patients had a medication history and fever. Among them, 90.9% patients had erythema morbilliforme, 90.9% had liver damage, 18.2% had renal damage, 54.5% had superficial lymph node enlargement and 36.4% had granulocytosis. Five patients had serious complications. One patient was complicated by autoimmune hemolytic anemia, 3 patients had transaminase elevated greater than 10 times and 1 patient died due to hepatic failure, hepatic encephalopathy and multiple organ failure. The treatment mainly included the use of glucocorticoid and gamma globulin, and, if necessary, plasma exchange. Conclusion The incubation period of children with DIHS is long, and the skin lesions are mainly erythema morbilliforme. Most of the affected organs are mainly liver, and some of patients can be combined with eosinophilia. Glucocorticoid therapy is effective.