Preliminary Study of the Neurovascular Effect of Electroacupuncture and Adrenomedullin in Cerebral Ischemia-reperfusion Injury
10.13460/j.issn.1005-0957.2017.07.0846
- VernacularTitle:电针和肾上腺髓质素抗脑缺血再灌注损伤中神经血管效应的初步研究
- Author:
Mingshu XU
;
Qing HAN
;
Yingjie ZHANG
;
Chunyan CHEN
;
Linbao GE
- Keywords:
Electroacupuncture;
Ischemia and reperfusion;
Adrenomedullin;
Rats;
Somatosensory evoked potential
- From:
Shanghai Journal of Acupuncture and Moxibustion
2017;36(7):846-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily reveal the neurovascular effect of electroacupuncture and adrenomedullin (ADM) in cerebral ischemia-reperfusion injury.Methods Rat changes after middle cerebral artery ischemia and reperfusion, and the effect of electroacupuncture and ADM on them were investigated using the neurological deficit score, somatosensory evoked potentials and TTC staining technique.Results Electroacupuncture and ADM can significantly improve the neurological deficit score after cerebral ischemia and reperfusion (P<0.05), but there was no significant difference between the two (P>0.05). The P1-N1 and N1-P2 peak values of somatosensory evoked potentials decreased significantly at 30 min after ischemia (P<0.05), recovered somewhat at 60 minutes and decreased significantly again during reperfusion (P<0.05). Electroacupuncture or ADM during reperfusion could significantly improved somatosensory evoked potentials at the end of experiment (P<0.05). Electroacupuncture and ADM could significantly reduce the size of cerebral ischemia-induced infarct (P<0.05), but there was no significant differencebetween the two (P>0.05).Conclusions Electroacupuncture can reduce neurological impairment and improve brain blood supply after cerebral ischemia and reperfusion. That is similar to the neurovascular effect of ADM.
