Comparison of the prognosis of liver resection and transcatheter arterial chemoembolization for patients with Barcelona clinic liver stage C and portal vein tumor thrombus
10.11659/jjssx.04E017011
- VernacularTitle:手术切除与介入治疗巴塞罗那C期肝癌伴门静脉癌栓患者预后比较
- Author:
Yi WANG
;
Zhenhua YANG
;
Shangzhu BO
;
Jun XU
;
Honggen QIU
- Keywords:
hepatocellular carcinoma;
liver resection;
transcatheter arterial chemoembolization;
barcelona clinic liver cancer stage c;
overall survival
- From:
Journal of Regional Anatomy and Operative Surgery
2017;26(7):509-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the long time prognosis of liver resection or transcatheter arterial chemoembolization(TACE) of Barcelona clinic liver cancer stage C(BCLC-C) patients who have portal vein tumor thrombsis.Methods Totally 86 BCLC-C patients who satisfied our including criteria from our surgical database of People's Hospital of Yichang City from January 2000 to September 2015 were selected as the research object.According to different treatment,86 patients were divided into liver resection group(n=50) and TACE group(n=36).The general information of two groups were compared.Cox multi-factors analysis and overall survival rate were calculated.ResultsThe long-term prognosis of liver resection group was better than that of TACE group(5-year OS:26% vs.0,P<0.001).Multi-factors analysis revealed that multiple tumors (HR:1.510,95%CI[1.120,2.316],P=0.020),AST>40 IU/L(HR:0.615,95%CI[0.488,1.206],P=0.013) as well as HBV-DNA>1 000(HR:1.204,95%CI:[0.920,2.540],P=0.038)were adverse factors for prognosis.ConclusionLiver resection is better than TACE for BCLC-C patients with portal vein tumor thrombosis.However,randomized controlled trial still need to be used to further confirm our conclusion.
