Integrating of the gene expression profiles in gallbladder stone and identify regulatory networks
10.3969/j.issn.1007-1989.2017.07.015
- VernacularTitle:内镜保胆胆囊组织结石复发易感基因调控研究
- Author:
Xu XU
;
Quanfu LI
;
Liguang ZHANG
- Keywords:
susceptibility gene;
high-throughput sequencing;
stone recurrence;
differentially expressed genes
- From:
China Journal of Endoscopy
2017;23(7):71-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective The gene expression profile of gallbladder stone and gallbladder polyp were analyzed by high-throughput sequencing technology to explore the roles of the gene in the development of gallstone and their molecular mechanism in the occurrence and development of gallbladder stone. Methods 7 patients with gallstones and 2 patients with gallbladder polyp was enrolled for RNA-Seq. Results 150 DEGs was identified between gallstones and gallbladder polyps. We found GO terms for molecular functions significantly enriched in antigen binding, while for biological processes, the enriched GO terms were immune response, and for cellular component, the enriched GO terms were extracellular region. The most significant pathway in our KEGG analysis was Cytokine-cytokine receptor interaction (P = 0.000). Conclusion This present study suggests some promising genes may provide a clue to the role of these genes played in the development of gallstones and gallbladder polyps.
