Correlation analysis between T lymphocyte subsets, neutrophilto lymphocyte ratio and lung cancer pathological classificationand clinical stage of non-small cell lung cancer
10.19405/j.cnki.issn1000-1492.2017.06.030
- VernacularTitle:T细胞亚群、中性淋巴比值与肺癌病理分型及非小细胞肺癌临床分期的相关性分析
- Author:
Yujie WU
;
Dahai ZHAO
- Keywords:
lung cancer;
T lymphocyte subsets;
neutrophil to lymphocyte ratio;
pathological classification;
clinical stage
- From:
Acta Universitatis Medicinalis Anhui
2017;52(6):912-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between T lymphocyte subsets,neutrophil to lymphocyte ratio(NLR) and lung cancer pathological classification,clinical stage of non-small cell lung cancer.Methods The proportion of T lymphocyte subsets in 60 patients with lung cancer were detected by flow cytometry,the NLR were measured by blood sampling.Results The proportion of CD4+T lymphocytes,the proportion of CD8+T lymphocytes,CD4+/CD8+ and NLR in patients with lung adenocarcinoma,lung squamous cell carcinoma,small cell lung cancer patients were not statistically significant.The proportion of CD4+T lymphocytes and CD4+/CD8+ in patients with advanced non-small cell lung cancer(stage Ⅲ~Ⅳ) were lower(P<0.05) than in the early group(stage Ⅰ~Ⅱ).The proportion of CD8+T lymphocytes and NLR in patients with advanced non-small cell lung cancer(stage Ⅲ~Ⅳ) were higher(P<0.05) than that of early stage group(stage Ⅰ~Ⅱ).Conclusion The T lymphocyte subsets and NLR in the peripheral blood of non-small cell lung cancer patients have a certain correlation with the clinical stage of non-small cell lung cancer,which can be used as a reference index for clinical staging.
