Role of TPMT Genetic Polymorphism in the Individualized Treatment of Thiopurine Drug
10.3969/j.issn.1671-7414.2017.03.001
- VernacularTitle:TPMT遗传多态性在硫嘌呤类药物个体化治疗中的意义
- Author:
Yueping LIU
;
Hanqing XU
;
Ming LI
;
Qing HUANG
;
Weiling FU
- Keywords:
TPMT;
thiopurine drugs;
individualized drug dosing;
single nucleotide polymorphism
- From:
Journal of Modern Laboratory Medicine
2017;32(3):1-5,10
- CountryChina
- Language:Chinese
-
Abstract:
Thiopurine S-methyltransferase (TPMT) is an important and key cytoplasmic enzyme in the metabolism of thiopurine drugs,whose activity can directly determine the amount of thiopurine drugs metabolized to cytotoxic 6-thioguanine nucleotides and consequently influence clinical efficacy and adverse drug reactions of thiopurine drugs.In order to deepen knowledge and role of genetic polymorphism of tpmt in the individualized thiopurine drug treatment,this present review mainly covered the following three frequently concerned aspects,including i) whether or not to determine the activity of TPMT priot to treatment of thiopurine drugs;ii) to genotype or to phenotype;iii) how to choose genotype methods.
